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- Title
ERAD: the long road to destruction.
- Authors
Meusser, Birgit; Hirsch, Christian; Jarosch, Ernst; Sommer, Thomas
- Abstract
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or unassembled proteins from the ER. ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin-proteasome system (UPS). The spatial separation between substrate selection and degradation in ERAD requires substrate transport from the ER to the cytoplasm by a process termed dislocation. In this review, we will summarize advances in various aspects of ERAD and discuss new findings on how substrate dislocation is achieved.
- Publication
Nature cell biology, 2005, Vol 7, Issue 8, p766
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb0805-766