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- Title
The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly.
- Authors
Hetzer, Martin; Gruss, Oliver J; Mattaj, Iain W
- Abstract
The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope--that is, large quantities in the nucleus compared with small quantities in the cytoplasm--determines the directionality of many nuclear transport processes. Recent findings that Ran also functions in spindle formation and nuclear envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred processes. Ran functions in these events as a signal for chromosome position.
- Publication
Nature cell biology, 2002, Vol 4, Issue 7, pE177
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb0702-e177