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- Title
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
- Authors
Wulf, Gerburg; Finn, Greg; Suizu, Futoshi; Lu, Kun Ping
- Abstract
The prolyl isomerase Pin1 is a conserved enzyme that is intimately involved in diverse biological processes and pathological conditions such as cancer and Alzheimer's disease. By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by a proline residue (pSer/Thr-Pro), Pin1 can have profound effects on phosphorylation signalling. The structural and functional differences that result from cis-trans isomerization of specific pSer/Thr-Pro motifs probably underlie most, if not all, Pin1-dependent actions. Phosphorylation-dependent prolyl isomerization by Pin1 remains a unique mode for the modulation of signal transduction. Here, we provide an overview of the plethora of regulatory events that involve this unique enzyme, with a particular focus on oncogenic signalling and neurodegeneration.
- Publication
Nature cell biology, 2005, Vol 7, Issue 5, p435
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb0505-435