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- Title
Taking a bite: proteasomal protein processing.
- Authors
Rape, Michael; Jentsch, Stefan
- Abstract
The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcription factors NF-kappa B, Spt23p and Mga2p, which are generated from precursors by proteasomal processing. How distinct protein domains are spared from degradation remains a matter of debate. Here, we discuss several models and suggest a novel mechanism for proteasomal processing.
- Publication
Nature cell biology, 2002, Vol 4, Issue 5, pE113
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb0502-e113