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- Title
Generation of cloned transgenic pigs rich in omega-3 fatty acids.
- Authors
Liangxue Lai; Kang, Jing X.; Rongfeng Li; Jingdong Wang; Witt, William T.; Hwan Yul Yong; Yanhong Hao; Wax, David M.; Murphy, Clifton N.; Rieke, August; Samuel, Melissa; Linville, Michael L.; Korte, Scott W.; Evans, Rhobert W.; Starzl, Thomas E.; Prather, Randall S.; Dai, Yifan
- Abstract
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 4, p435
- ISSN
1087-0156
- Publication type
Academic Journal
- DOI
10.1038/nbt1198