We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic rescue of an endangered mammal by cross-species nuclear transfer using post-mortem somatic cells.
- Authors
Loi, P; Ptak, G; Barboni, B; Fulka, J, Jr; Cappai, P; Clinton, M
- Abstract
Since the advent of procedures for cloning animals, conservation biologists have proposed using this technology to preserve endangered mammals. Here we report the successful cloning of a wild endangered animal, Ovis orientalis musimon, using oocytes collected from a closely related, domesticated species, Ovis aries. We injected enucleated sheep oocytes with granulosa cells collected from two female mouflons found dead in the pasture. Blastocyst-stage cloned embryos transferred into sheep foster mothers established two pregnancies, one of which produced an apparently normal mouflon. Our findings support the use of cloning for the expansion of critically endangered populations.
- Publication
Nature biotechnology, 2001, Vol 19, Issue 10, p962
- ISSN
1087-0156
- Publication type
Journal Article
- DOI
10.1038/nbt1001-962