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- Title
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.
- Authors
Blum, Barak; Hrvatin, Siniša; Schuetz, Christian; Bonal, Claire; Rezania, Alireza; Melton, Douglas A
- Abstract
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
- Publication
Nature biotechnology, 2012, Vol 30, Issue 3, p261
- ISSN
1546-1696
- Publication type
Journal Article
- DOI
10.1038/nbt.2141