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- Title
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
- Authors
Terada, Naohiro; Hamazaki, Takashi; Oka, Masahiro; Hoki, Masanori; Mastalerz, Diana M; Nakano, Yuka; Meyer, Edwin M; Morel, Laurence; Petersen, Bryon E; Scott, Edward W
- Abstract
Recent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many others. A potential problem, however, is that reports discussing such 'transdifferentiation' in vivo tend to conclude donor origin of transdifferentiated cells on the basis of the existence of donor-specific genes such as Y-chromosome markers. Here we demonstrate that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3. Moreover, spontaneously fused bone marrow cells can subsequently adopt the phenotype of the recipient cells, which, without detailed genetic analysis, might be interpreted as 'dedifferentiation' or transdifferentiation.
- Publication
Nature, 2002, Vol 416, Issue 6880, p542
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/nature730