We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neural mechanisms of ageing and cognitive decline.
- Authors
Bishop, Nicholas A; Lu, Tao; Yankner, Bruce A
- Abstract
During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest health threats of old age, with nearly 50% of adults over the age of 85 afflicted with Alzheimer's disease. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain ageing. Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline.
- Publication
Nature, 2010, Vol 464, Issue 7288, p529
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature08983