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- Title
Bidirectional plasticity in fast-spiking GABA circuits by visual experience.
- Authors
Yazaki-Sugiyama, Yoko; Kang, Siu; Câteau, Hideyuki; Fukai, Tomoki; Hensch, Takao K
- Abstract
Experience-dependent plasticity in the brain requires balanced excitation-inhibition. How individual circuit elements contribute to plasticity outcome in complex neocortical networks remains unknown. Here we report an intracellular analysis of ocular dominance plasticity-the loss of acuity and cortical responsiveness for an eye deprived of vision in early life. Unlike the typical progressive loss of pyramidal-cell bias, direct recording from fast-spiking cells in vivo reveals a counterintuitive initial shift towards the occluded eye followed by a late preference for the open eye, consistent with a spike-timing-dependent plasticity rule for these inhibitory neurons. Intracellular pharmacology confirms a dynamic switch of GABA (gamma-aminobutyric acid) impact to pyramidal cells following deprivation in juvenile mice only. Together these results suggest that the bidirectional recruitment of an initially binocular GABA circuit may contribute to experience-dependent plasticity in the developing visual cortex.
- Publication
Nature, 2009, Vol 462, Issue 7270, p218
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature08485