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- Title
Function and biogenesis of iron-sulphur proteins.
- Authors
Lill, Roland
- Abstract
Iron-sulphur (Fe-S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the relative simplicity of Fe-S clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells. Different biogenesis machineries in both bacteria and eukaryotes have been discovered that assist Fe-S-protein maturation according to uniform biosynthetic principles. The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis.
- Publication
Nature, 2009, Vol 460, Issue 7257, p831
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature08301