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- Title
The structure and function of G-protein-coupled receptors.
- Authors
Rosenbaum, Daniel M; Rasmussen, Søren G F; Kobilka, Brian K
- Abstract
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.
- Publication
Nature, 2009, Vol 459, Issue 7245, p356
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature08144