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- Title
Driving fast-spiking cells induces gamma rhythm and controls sensory responses.
- Authors
Cardin, Jessica A; Carlén, Marie; Meletis, Konstantinos; Knoblich, Ulf; Zhang, Feng; Deisseroth, Karl; Tsai, Li-Huei; Moore, Christopher I
- Abstract
Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
- Publication
Nature, 2009, Vol 459, Issue 7247, p663
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature08002