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- Title
The promises and pitfalls of RNA-interference-based therapeutics.
- Authors
Castanotto, Daniela; Rossi, John J
- Abstract
The discovery that gene expression can be controlled by the Watson-Crick base-pairing of small RNAs with messenger RNAs containing complementary sequence - a process known as RNA interference - has markedly advanced our understanding of eukaryotic gene regulation and function. The ability of short RNA sequences to modulate gene expression has provided a powerful tool with which to study gene function and is set to revolutionize the treatment of disease. Remarkably, despite being just one decade from its discovery, the phenomenon is already being used therapeutically in human clinical trials, and biotechnology companies that focus on RNA-interference-based therapeutics are already publicly traded.
- Publication
Nature, 2009, Vol 457, Issue 7228, p426
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature07758