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- Title
Copy-number variations associated with neuropsychiatric conditions.
- Authors
Cook, Edwin H, Jr; Scherer, Stephen W
- Abstract
Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation--a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged--in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context.
- Publication
Nature, 2008, Vol 455, Issue 7215, p919
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature07458