We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
- Authors
King, Nicole; Westbrook, M Jody; Young, Susan L; Kuo, Alan; Abedin, Monika; Chapman, Jarrod; Fairclough, Stephen; Hellsten, Uffe; Isogai, Yoh; Letunic, Ivica; Marr, Michael; Pincus, David; Putnam, Nicholas; Rokas, Antonis; Wright, Kevin J; Zuzow, Richard; Dirks, William; Good, Matthew; Goodstein, David; Lemons, Derek; Li, Wanqing; Lyons, Jessica B; Morris, Andrea; Nichols, Scott; Richter, Daniel J; Salamov, Asaf; Sequencing, J G I; Bork, Peer; Lim, Wendell A; Manning, Gerard; Miller, W Todd; McGinnis, William; Shapiro, Harris; Tjian, Robert; Grigoriev, Igor V; Rokhsar, Daniel
- Abstract
Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome of the unicellular choanoflagellate Monosiga brevicollis. The genome contains approximately 9,200 intron-rich genes, including a number that encode cell adhesion and signalling protein domains that are otherwise restricted to metazoans. Here we show that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans.
- Publication
Nature, 2008, Vol 451, Issue 7180, p783
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature06617