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- Title
Genotyping of Rhesus SCNT pluripotent stem cell lines.
- Authors
Cram, David S.; Song, Bi; Trounson, Alan O.
- Abstract
Arising from: J. A. Byrne et al. 450, doi: 10.1038/nature06357 (2007)Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al. report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies detailed in their paper provides supporting evidence that the chromosome complement of CRES-1 and CRES-2 was genetically identical to the male cell donor nucleus and that the mitochondrial DNA originated from different recipient oocytes. In this validation paper, we independently confirm that both stem cell lines were indeed derived by SCNT.
- Publication
Nature, 2007, Vol 450, Issue 7169, pE12
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/nature06456