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- Title
Taking dendritic cells into medicine.
- Authors
Steinman, Ralph M; Banchereau, Jacques
- Abstract
Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with DC-targeted vaccines. During allergy, autoimmunity and transplant rejection, DCs instigate unwanted responses that cause disease, but, again, DCs can be harnessed to silence these conditions with novel therapies. Here we present some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy.
- Publication
Nature, 2007, Vol 449, Issue 7161, p419
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature06175