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- Title
Two neurons mediate diet-restriction-induced longevity in C. elegans.
- Authors
Bishop, Nicholas A; Guarente, Leonard
- Abstract
Dietary restriction extends lifespan and retards age-related disease in many species and profoundly alters endocrine function in mammals. However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated. Here we show that increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head. Dietary restriction activates skn-1 in these two neurons, which signals peripheral tissues to increase metabolic activity. These findings demonstrate that increased lifespan in a diet-restricted metazoan depends on cell non-autonomous signalling from central neuronal cells to non-neuronal body tissues, and suggest that the ASI neurons mediate diet-restriction-induced longevity by an endocrine mechanism.
- Publication
Nature, 2007, Vol 447, Issue 7144, p545
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature05904