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- Title
Exploiting the defensive sugars of HIV-1 for drug and vaccine design.
- Authors
Scanlan, Christopher N; Offer, John; Zitzmann, Nicole; Dwek, Raymond A
- Abstract
The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.
- Publication
Nature, 2007, Vol 446, Issue 7139, p1038
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature05818