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- Title
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.
- Authors
Mikkelsen, Tarjei S; Wakefield, Matthew J; Aken, Bronwen; Amemiya, Chris T; Chang, Jean L; Duke, Shannon; Garber, Manuel; Gentles, Andrew J; Goodstadt, Leo; Heger, Andreas; Jurka, Jerzy; Kamal, Michael; Mauceli, Evan; Searle, Stephen M J; Sharpe, Ted; Baker, Michelle L; Batzer, Mark A; Benos, Panayiotis V; Belov, Katherine; Clamp, Michele; Cook, April; Cuff, James; Das, Radhika; Davidow, Lance; Deakin, Janine E; Fazzari, Melissa J; Glass, Jacob L; Grabherr, Manfred; Greally, John M; Gu, Wanjun; Hore, Timothy A; Huttley, Gavin A; Kleber, Michael; Jirtle, Randy L; Koina, Edda; Lee, Jeannie T; Mahony, Shaun; Marra, Marco A; Miller, Robert D; Nicholls, Robert D; Oda, Mayumi; Papenfuss, Anthony T; Parra, Zuly E; Pollock, David D; Ray, David A; Schein, Jacqueline E; Speed, Terence P; Thompson, Katherine; VandeBerg, John L; Wade, Claire M; Walker, Jerilyn A; Waters, Paul D; Webber, Caleb; Weidman, Jennifer R; Xie, Xiaohui; Zody, Michael C; Graves, Jennifer A Marshall; Ponting, Chris P; Breen, Matthew; Samollow, Paul B; Lander, Eric S; Lindblad-Toh, Kerstin; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team
- Abstract
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.
- Publication
Nature, 2007, Vol 447, Issue 7141, p167
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature05805