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- Title
Inflammation and metabolic disorders.
- Authors
Hotamisligil, Gökhan S
- Abstract
Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.
- Publication
Nature, 2006, Vol 444, Issue 7121, p860
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature05485