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- Title
Mechanisms linking obesity to insulin resistance and type 2 diabetes.
- Authors
Kahn, Steven E; Hull, Rebecca L; Utzschneider, Kristina M
- Abstract
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet beta-cells - the cells that release insulin - failure to control blood glucose levels results. Abnormalities in beta-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.
- Publication
Nature, 2006, Vol 444, Issue 7121, p840
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature05482