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- Title
Stem cells, ageing and the quest for immortality.
- Authors
Rando, Thomas A
- Abstract
Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.
- Publication
Nature, 2006, Vol 441, Issue 7097, p1080
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature04958