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- Title
Introns and the origin of nucleus-cytosol compartmentalization.
- Authors
Martin, William; Koonin, Eugene V
- Abstract
The origin of the eukaryotic nucleus marked a seminal evolutionary transition. We propose that the nuclear envelope's incipient function was to allow mRNA splicing, which is slow, to go to completion so that translation, which is fast, would occur only on mRNA with intact reading frames. The rapid, fortuitous spread of introns following the origin of mitochondria is adduced as the selective pressure that forged nucleus-cytosol compartmentalization.
- Publication
Nature, 2006, Vol 440, Issue 7080, p41
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature04531