We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
- Authors
Duo Wang; Kennedy, Scott; Conte Jr., Darryl; Kim, John K.; Gabel, Harrison W.; Kamath, Ravi S.; Mello, Craig C.; Ruvkun, Gary
- Abstract
Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex specify cell lineage during development. Here we show that mutations in Rb pathway components enhance RNA interference (RNAi) and cause somatic cells to express genes and elaborate perinuclear structures normally limited to germline-specific P granules. Furthermore, particular gene inactivations that disrupt RNAi reverse the cell lineage transformations of Rb pathway mutants. These findings suggest that mutations in Rb pathway components cause cells to revert to patterns of gene expression normally restricted to germ cells. Rb may act by a similar mechanism to transform mammalian cells.
- Publication
Nature, 2005, Vol 436, Issue 7050, p593
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/nature04010