We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biochemistry: role of PQQ as a mammalian enzyme cofactor?
- Authors
Felton, Leigh M; Anthony, Chris
- Abstract
The announcement by Kasahara and Kato of a new redox-cofactor vitamin for mammals, pyrroloquinoline quinone (PQQ), was based on their claim that an enzyme, predicted to be involved in mouse lysine metabolism, is a PQQ-dependent dehydrogenase. However, this claim was dependent on a sequence analysis using databases that inappropriately label beta-propeller sequences as PQQ-binding motifs. What the evidence actually suggests is that the enzyme is an interesting novel protein that has a seven-bladed beta-propeller structure, but there is nothing to indicate that it is a PQQ-dependent dehydrogenase.
- Publication
Nature, 2005, Vol 433, Issue 7025, pE10
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature03322