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- Title
Mice cloned from olfactory sensory neurons.
- Authors
Eggan, Kevin; Baldwin, Kristin; Tackett, Michael; Osborne, Joseph; Gogos, Joseph; Chess, Andrew; Axel, Richard; Jaenisch, Rudolf
- Abstract
Cloning by nuclear transplantation has been successfully carried out in various mammals, including mice. Until now mice have not been cloned from post-mitotic cells such as neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of odorant receptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguishable from wild-type animals, indicating that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.
- Publication
Nature, 2004, Vol 428, Issue 6978, p44
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature02375