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- Title
Protein degradation and protection against misfolded or damaged proteins.
- Authors
Goldberg, Alfred L
- Abstract
The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This process is of particular importance in protecting cells against harsh conditions (for example, heat shock or oxidative stress) and in a variety of diseases (for example, cystic fibrosis and the major neurodegenerative diseases). A full understanding of the pathogenesis of the protein-folding diseases will require greater knowledge of how misfolded proteins are recognized and selectively degraded.
- Publication
Nature, 2003, Vol 426, Issue 6968, p895
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/nature02263