We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii.
- Authors
Carlton, Jane M; Angiuoli, Samuel V; Suh, Bernard B; Kooij, Taco W; Pertea, Mihaela; Silva, Joana C; Ermolaeva, Maria D; Allen, Jonathan E; Selengut, Jeremy D; Koo, Hean L; Peterson, Jeremy D; Pop, Mihai; Kosack, Daniel S; Shumway, Martin F; Bidwell, Shelby L; Shallom, Shamira J; van Aken, Susan E; Riedmuller, Steven B; Feldblyum, Tamara V; Cho, Jennifer K; Quackenbush, John; Sedegah, Martha; Shoaibi, Azadeh; Cummings, Leda M; Florens, Laurence; Yates, John R; Raine, J Dale; Sinden, Robert E; Harris, Michael A; Cunningham, Deirdre A; Preiser, Peter R; Bergman, Lawrence W; Vaidya, Akhil B; van Lin, Leo H; Janse, Chris J; Waters, Andrew P; Smith, Hamilton O; White, Owen R; Salzberg, Steven L; Venter, J Craig; Fraser, Claire M; Hoffman, Stephen L; Gardner, Malcolm J; Carucci, Daniel J
- Abstract
Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.
- Publication
Nature, 2002, Vol 419, Issue 6906, p512
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/nature01099