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Title
Comprehensive proteomic analysis of the human spliceosome.
Authors
Zhaolan Zhou; Licklider, Lawrence J.; Gygi, Steven P.; Reed, Robin
Abstract
Provides a comprehensive proteomic analysis of the human spliceosome. Use of maltose-binding protein affinity chromatography to isolate spliceosomes in highly purified and functional form; Thirty proteins with known or putative roles in gene expression contained in the spliceosome; Mediating the extensive coupling between splicing and other steps in gene expression.