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- Title
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
- Authors
Smith, G D; Gunthorpe, M J; Kelsell, R E; Hayes, P D; Reilly, P; Facer, P; Wright, J E; Jerman, J C; Walhin, J-P; Ooi, L; Egerton, J; Charles, K J; Smart, D; Randall, A D; Anand, P; Davis, J B
- Abstract
Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Although VR1 gene disruption results in a loss of capsaicin responses, it has minimal effects on thermal nociception. This and other experiments--such as those showing the existence of capsaicin-insensitive heat sensors in sensory neurons--suggest the existence of thermosensitive receptors distinct from VR1. Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive. VRL3 is coded for by a 2,370-base-pair open reading frame, transcribed from a gene adjacent to VR1, and is structurally homologous to VR1. VRL3 responds to noxious heat with a threshold of about 39 degrees C and is co-expressed in dorsal root ganglion neurons with VR1. Furthermore, when heterologously expressed, VRL3 is able to associate with VR1 and may modulate its responses. Hence, not only is VRL3 a thermosensitive ion channel but it may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels.
- Publication
Nature, 2002, Vol 418, Issue 6894, p186
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/nature00894