We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TGFβ1, an epidermal controller of skin dendritic cell homeostasis.
- Authors
Kitoh, Akihiko; Nomura, Takashi; Kabashima, Kenji
- Abstract
Transforming growth factor-β1 (TGFβ1) is generally regarded as an anti-inflammatory cytokine. However, previous studies suggest that TGFβ1 can promote immune responses under certain conditions. In this issue, Mohammed et al. report that epidermal keratinocyte-derived TGFβ1 alone can alter homeostasis of multiple cutaneous dendritic cell (DC) subsets, which may enhance skin inflammation. These findings may provide a better understanding of the pathogenesis of inflammatory skin disorders such as psoriasis, although how keratinocyte-derived TGFβ1 regulates cutaneous DCs under physiological and inflammatory conditions should be further addressed.
- Publication
The Journal of investigative dermatology, 2013, Vol 133, Issue 1, p9
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/jid.2012.411