We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
IL-17: important for host defense, autoimmunity, and allergy?
- Authors
Lee, F Eun-Hyung; Georas, Steve N; Beck, Lisa A
- Abstract
In this issue, Milovanovic and colleagues present evidence that IL-17a enhances IgE production, although the precise mechanism remains unclear. Their initial finding was that higher numbers of IL-17a-producing CD4(+) T cells were observed after polyclonal stimulation in a largely airway allergic population. These data add to the evidence that atopic disorders such as asthma and, possibly, atopic dermatitis (AD) may have distinct immunologic phenotypes. The hope is that by characterizing the immunologic basis of these common diseases we will be able to understand the heterogeneity observed in natural history, response to treatments, susceptibility to infections, genetic risk factors, and associations with other atopic disorders.
- Publication
The Journal of investigative dermatology, 2010, Vol 130, Issue 11, p2540
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/jid.2010.295