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- Title
The IL-23/Th17 axis in the immunopathogenesis of psoriasis.
- Authors
Di Cesare, Antonella; Di Meglio, Paola; Nestle, Frank O
- Abstract
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.
- Publication
The Journal of investigative dermatology, 2009, Vol 129, Issue 6, p1339
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/jid.2009.59