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- Title
Flii control: balancing migration and adhesion.
- Authors
Kligys, Kristina; Jones, Jonathan C R
- Abstract
Wound healing in the skin requires a compromise between adhesion and migration. Both processes include modulation of the cytoskeleton, cell-surface receptors, and receptor ligands., In this issue, Kopecki et al. demonstrate that overexpression of Flii, an actin-remodeling protein, impedes wound healing but inhibits hemidesmosome formation. In contrast, Flii deficiency results in enhanced wound healing while promoting hemidesmosome assembly. We discuss potential mechanisms that could explain how this unique gelsolin family member might regulate both stable keratinocyte adhesion and motility.
- Publication
The Journal of investigative dermatology, 2009, Vol 129, Issue 8, p1856
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/jid.2009.171