We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Eczema genetics: current state of knowledge and future goals.
- Authors
Brown, Sara J; McLean, W H Irwin
- Abstract
Multiple genetic as well as environmental factors interact in the pathogenesis of eczema. Increased understanding of genetic predisposition in atopy and eczema has directed interest toward key pathogenic mechanisms including skin barrier dysfunction. This review provides a succinct update on the current state of knowledge regarding eczema genetics. We discuss the relevance of loss-of-function mutations in the filaggrin gene within the context of other candidate gene studies and suggest possible applications for future research. Knowledge of genetic factors in eczema may translate into a clearer understanding of pathogenic mechanisms and hence more focused therapeutic strategies, but this remains at present a distant possibility.
- Publication
The Journal of investigative dermatology, 2009, Vol 129, Issue 3, p543
- ISSN
1523-1747
- Publication type
Journal Article
- DOI
10.1038/jid.2008.413