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- Title
Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism.
- Authors
Bikle, Daniel D
- Abstract
More than 1 million skin cancers occur annually in the United States--of which 80% are basal-cell carcinoma (BCC), 16% are squamous-cell carcinoma (SCC), and 4% are melanomas--making skin cancer by far the most common cancer (Greenlee et al., 2001). UVR is the major etiologic agent. UV wavelengths shorter than 280 nm (UVC) are absorbed by the ozone layer and do not reach the earth. UV wavelengths longer than 320 nm (UVA) have limited ability to induce the characteristic mutations in DNA seen in epidermal cancers. Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?
- Publication
The Journal of investigative dermatology, 2008, Vol 128, Issue 10, p2357
- ISSN
1523-1747
- Publication type
Research
- DOI
10.1038/jid.2008.249