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- Title
Pigmentation Genes: the Tyrosinase Gene Family and the pmel 17 Gene Family.
- Authors
Kwon, Byoung S.
- Abstract
We propose that at least two families of genes regulate the melanin biosynthesis. The first is the tyrosinase gene family, which is comprised of tyrosinase (<em>c</em> locus), gp75 (<em>b</em> locus) and DOPAchrome tautomerase (<em>slt</em> locus). The second is the pmel 17 gene family, which is composed of pmel 17 (putative <em>si</em> locus) and chicken melanosomal matrix protein (MMP) 115. It appears that the tyrosinase gene family regulates melanin synthesis in the proximal steps of the melanin biosynthetic pathway and the pmel 17 gene family might be important at distal steps of the pathway.
- Publication
Journal of Investigative Dermatology, 1993, Vol 100, p134S
- ISSN
0022-202X
- Publication type
Academic Journal
- DOI
10.1038/jid.1993.2