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- Title
Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution.
- Authors
Sin, Ho-Su; Koh, Eitetsu; Kim, Dae-Soo; Murayama, Miho; Sugimoto, Kazuhiro; Maeda, Yuji; Yoshida, Atsumi; Namiki, Mikio
- Abstract
The male-specific region of Y chromosome (MSY) has accumulated a higher density of human endogenous retroviruses (HERVs) and related sequences when compared with other regions of the human genome. Here, we focused on one HERV family, HERV-K14C that seemed to integrate preferentially into the Y chromosome in humans. To identify every copies of HERV-K14C in the human genome, we applied computational screening to map precisely the locus of individual HERV-K14C copies. Interestingly, 29 of all 146 copies were located in Y chromosome, and these 29 copies were mostly dispersed in the palindromic region. Three distinct HERV-K14C-related transcripts were found and were exclusively expressed in human testis tissue. Based on our phylogenetic analysis of the solitary LTRs derived from HERV-K14C on the Y chromosome we suggested that these sequences were generated as pairs of identical sequences. Specifically, analysis of HERV-K14C-related sequences in the palindromic region demonstrated that the Y chromosomal amplicons existed in our common ancestors and the duplicated pairs arose after divergence of great apes approximately 8-10 million years ago. Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage.
- Publication
Journal of human genetics, 2010, Vol 55, Issue 11, p717
- ISSN
1435-232X
- Publication type
Journal Article
- DOI
10.1038/jhg.2010.94