We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of genetic loci influencing adult height in the Japanese population.
- Authors
Takeuchi, Fumihiko; Nabika, Toru; Isono, Masato; Katsuya, Tomohiro; Sugiyama, Takao; Yamaguchi, Shuhei; Kobayashi, Shotai; Yamori, Yukio; Ogihara, Toshio; Kato, Norihiro
- Abstract
Adult height is a highly heritable, classic polygenic trait. The recent advent of genome-wide association studies has led to the identification of robust association at common variants influencing the normal variation of height; the number of loci has now risen to 50. The present study tested the potential overlap of height associations at 46 loci that were previously reported in European-descent populations with those among 1530 Japanese subjects and also attempted to replicate the suggestive association signals that were previously reported in East Asians alone. We found a total of 20 independent loci to be significantly (P<0.05) associated with height among the Japanese subjects (N< or =6814); 19 loci were originally identified in Europeans and the remaining 1 locus (ZFAT) was previously reported in Koreans (P=3.8 x 10(-9) with the Japanese and Korean data combined for ZFAT). Although 41% (19 of 46) of the loci were nominally replicated, a higher proportion of the tested loci seemed to overlap between the Japanese and Europeans; 83% (38 of 46) of the loci showed a concordant direction of association between the two ethnic groups. Despite the substantial inter-population overlap observed in the present study, further investigation is warranted to search for loci with enhanced genetic impacts in East Asians than in Europeans.
- Publication
Journal of human genetics, 2009, Vol 54, Issue 12, p749
- ISSN
1435-232X
- Publication type
Journal Article
- DOI
10.1038/jhg.2009.99