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- Title
Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus.
- Authors
Chowdhury, Golam M I; Banasr, Mounira; de Graaf, Robin A; Rothman, Douglas L; Behar, Kevin L; Sanacora, Gerard
- Abstract
Riluzole is believed to modulate glutamatergic function by reducing glutamate release and facilitating astroglial uptake. We measured (13)C labeling in metabolites in prefrontal cortex and hippocampus during a 10 mins infusion of [1-(13)C]glucose in urethane anesthetized rats treated with riluzole (21 days, 4 mg/kg per day, i.p.) or saline. Total and (13)C concentrations of metabolites were determined in extracts using (1)H-[(13)C] NMR spectroscopy. In prefrontal cortex (P<0.05) and hippocampus (P<0.05) riluzole increased (13)C labeling over saline in glutamate-C4 (to 112% and 130%), GABA-C2 (to 142% and 171%), and glutamine-C4 (to 118% and 233%) without affecting total metabolite levels (P>0.2). Our findings indicate that contrary to expectation chronic riluzole enhanced glucose oxidative metabolism and glutamate/glutamine cycling.
- Publication
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2008, Vol 28, Issue 12, p1892
- ISSN
1559-7016
- Publication type
Journal Article
- DOI
10.1038/jcbfm.2008.78