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- Title
Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935.
- Authors
Nachtigall, Jonny; Schneider, Kathrin; Bruntner, Christina; Bull, Alan T; Goodfellow, Michael; Zinecker, Heidi; Imhoff, Johannes F; Nicholson, Graeme; Irran, Elisabeth; Süssmuth, Roderich D; Fiedler, Hans-Peter
- Abstract
Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.
- Publication
The Journal of antibiotics, 2011, Vol 64, Issue 6, p453
- ISSN
1881-1469
- Publication type
Journal Article
- DOI
10.1038/ja.2011.26