We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Importance of reward and prefrontal circuitry in hunger and satiety: Prader-Willi syndrome vs simple obesity.
- Authors
Holsen, L M; Savage, C R; Martin, L E; Bruce, A S; Lepping, R J; Ko, E; Brooks, W M; Butler, M G; Zarcone, J R; Goldstein, J M
- Abstract
The majority of research on obesity (OB) has focused primarily on clinical features (eating behavior, adiposity measures) or peripheral appetite-regulatory peptides (leptin, ghrelin). However, recent functional neuroimaging studies have demonstrated that some reward circuitry regions that are associated with appetite-regulatory hormones are also involved in the development and maintenance of OB. Prader-Willi syndrome (PWS), characterized by hyperphagia and hyperghrelinemia reflecting multi-system dysfunction in inhibitory and satiety mechanisms, serves as an extreme model of genetic OB. Simple (non-PWS) OB represents an OB-control state.
- Publication
International journal of obesity (2005), 2012, Vol 36, Issue 5, p638
- ISSN
1476-5497
- Publication type
Journal Article
- DOI
10.1038/ijo.2011.204