We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regulation of LKB1 expression by sex hormones in adipocytes.
- Authors
McInnes, K J; Brown, K A; Hunger, N I; Simpson, E R
- Abstract
In the adipose tissue, activation of AMP-activated protein kinase (AMPK) by phosphorylation favours local fatty acid oxidation and inhibition of lipogenesis. We have previously shown that the potent androgen dihydrotestosterone (DHT) can inhibit phosphorylation of AMPK in adipose tissue and 3T3-L1 adipocytes in a dose-dependent manner. This negative effect of DHT was reversed by oestrogen treatment. The purpose of this current study was to determine the underlying mechanisms whereby androgens and oestrogens can regulate AMPK phosphorylation in adipocytes, and whether this mechanism is receptor dependent.
- Publication
International journal of obesity (2005), 2012, Vol 36, Issue 7, p982
- ISSN
1476-5497
- Publication type
Journal Article
- DOI
10.1038/ijo.2011.172