We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcriptional control of brown adipocyte development and thermogenesis.
- Authors
Seale, P
- Abstract
Brown adipose tissue (BAT) is a specialized endothermic tissue in eutherian mammals that protects against hypothermia. Heat production by BAT may also be stimulated by overfeeding as an apparent counter regulatory mechanism to prevent excessive adipose accumulation. Genetic studies in rodents have overwhelmingly demonstrated an antiobesity effect for BAT. There is thus substantial biomedical interest in developing methods to increase the amount or function of BAT as a means to combat obesity. Furthermore, the recent discovery that adult humans have rather significant amounts of active BAT raises speculation that this tissue may naturally affect body weight in humans. Recent advances in our understanding of the transcriptional regulation of brown adipocyte development and adaptive thermogenesis are reviewed here.
- Publication
International journal of obesity (2005), 2010, Vol 34 Suppl 1, pS17
- ISSN
1476-5497
- Publication type
Journal Article
- DOI
10.1038/ijo.2010.178