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- Title
The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity.
- Authors
Akpan, I; Goncalves, M D; Dhir, R; Yin, X; Pistilli, E E; Bogdanovich, S; Khurana, T S; Ucran, J; Lachey, J; Ahima, R S
- Abstract
Myostatin, also known as Growth and Differentiation Factor 8, is a secreted protein that inhibits muscle growth. Disruption of myostatin signaling increases muscle mass and decreases glucose, but it is unclear whether these changes are related. We treated mice on chow and high-fat diets with a soluble activin receptor type IIB (ActRIIB, RAP-031), which is a putative endogenous signaling receptor for myostatin and other ligands of the TGF-beta superfamily.
- Publication
International journal of obesity (2005), 2009, Vol 33, Issue 11, p1265
- ISSN
1476-5497
- Publication type
Journal Article
- DOI
10.1038/ijo.2009.162