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- Title
Genetic and environmental contributions to body mass index: comparative analysis of monozygotic twins, dizygotic twins and same-age unrelated siblings.
- Authors
Segal, N L; Feng, R; McGuire, S A; Allison, D B; Miller, S
- Abstract
Earlier studies have established that a substantial percentage of variance in obesity-related phenotypes is explained by genetic components. However, only one study has used both virtual twins (VTs) and biological twins and was able to simultaneously estimate additive genetic, non-additive genetic, shared environmental and unshared environmental components in body mass index (BMI). Our current goal was to re-estimate four components of variance in BMI, applying a more rigorous model to biological and virtual multiples with additional data. Virtual multiples share the same family environment, offering unique opportunities to estimate common environmental influence on phenotypes that cannot be separated from the non-additive genetic component using only biological multiples.
- Publication
International journal of obesity (2005), 2009, Vol 33, Issue 1, p37
- ISSN
1476-5497
- Publication type
Journal Article
- DOI
10.1038/ijo.2008.228