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- Title
A brief note on the resemblance between relatives in the presence of population stratification.
- Authors
Sebro, R; Risch, N J
- Abstract
Population stratification occurs when a study population is comprised of several sub-populations, and can result in increased false positive findings in genomewide-association studies. Recently published work shows that sub-population-specific positive assortative mating at the genotypic level results in population stratification. We show that if the allele frequency of a single nucleotide polymorphism responsible for a trait varies between sub-populations and there is no dominance variance, then the heritability of the trait increases, primarily due to an increase in the additive genetic variance of the trait.
- Publication
Heredity, 2012, Vol 108, Issue 5, p563
- ISSN
1365-2540
- Publication type
Journal Article
- DOI
10.1038/hdy.2011.124