We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human interferon-lambda3 is a potent member of the type III interferon family.
- Authors
Dellgren, C; Gad, H H; Hamming, O J; Melchjorsen, J; Hartmann, R
- Abstract
Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambdaR1 receptor chains. We have established a simple and efficient expression system to produce highly pure and active IFN-lambda of the three human IFN-lambda isoforms (IFN-lambda1, -lambda2 and -lambda3) and used this to compare the biological activity of the different IFN-lambda subtypes. Surprisingly, we found IFN-lambda3 to possess the highest specific activity of the human IFN-lambda subtypes, exhibiting a twofold higher activity than IFN-lambda1 and a 16-fold higher activity than IFN-lambda2. Furthermore, in comparison with the commercially available preparations of IFN-lambda1 and -lambda2, we found our IFN-lambda preparation to be superior in activity.
- Publication
Genes and immunity, 2009, Vol 10, Issue 2, p125
- ISSN
1476-5470
- Publication type
Journal Article
- DOI
10.1038/gene.2008.87